Someone died, and that meant it was time to sell off his land for a bunch of McMansions.
He was one of the last holdouts, selling fruits and vegetables at a roadside stand at Clayton and Schoettler roads. St. Louis County tax records show that the house has asbestos, so perhaps that is what is holding up the demolition. Take a look at Google Maps to see all the trees that used to be there.
Update: Demolished by late 2015.