While Ste. Genevieve is famous for being founded by French Canadian Catholics, there are other churches in town of historic importance, as well. Holy Cross Lutheran Church was founded in 1867, and reflects the increased German immigrant population in the area. In this case, it is interesting in that construction of the church began only months after the founding of the congregation.

First Presbyterian Church was founded in 1902, with the sanctuary being completed in 1904; chairs from the World’s Fair in St. Louis would furnish the interior. The adjacent building with more classrooms was built in 1954.