I think it’s important to realize that while yes, Ste. Genevieve is an important French colonial settlement, the vast majority of housing stock is from much later than the Eighteenth Century. Take these examples along and near Main Street. The river is much further away nowadays, thanks to the Army Corps of Engineers.
In fact, it seems like there are a lot of Queen Anne style houses, such as the one above and elsewhere in this post, obviously shorn of their millwork that has long rotted away.
Above and below, there are also a lot of very utilitarian structures that may or may not have originally been houses that were converted into businesses. They are very German in their gable roofs.
But you can see looking down the street how it would be very natural for a residential street to become more commercial.
Further north, however, the street becomes very quiet and strictly residential.